It may take time to see changes, especially if a washout period is needed. Comparing weight loss results Tirzepatide shows significantly better weight loss results in clinical studies: In a large study of over 18,000 patients, those taking tirzepatide lost about 15.3% of their body weight in one year, compared to 8.3% with semaglutide
This steady pharmacologic presence contributed to participants achieving up to 24% body weight reduction over 48 weeks, representing some of the most substantial results observed in obesity pharmacotherapy
Potga 2022) and TLK199 (Lv et al
The difference is subtle and does not indicate any chemical change
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