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These cells were maintained in DMEM/F-12 medium (11320033, Gibco) supplemented with 10% fetal bovine serum (abs972, Absin) and 1% penicillin-streptomycin solution (U31-301C, YOBIBIO), and cultured in a humidified constant-temperature incubator at 37 C with 5% CO 2

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