Given that cyanide exposure from linamarin is strongly associated with the development of konzo, an increase in plasma oxidative stress may also affect cyanide action or metabolism, potentially amplifying its capacity to induce mitochondrial stress or giving rise to its oxidized form cyanate, which is a strong neurotoxin in various experimental models that can further decrease glutathione levels in the CNS 52,53
These infusion regimens are not standardized and vary in duration, total dose, and frequency of treatment
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(4) The phenomenon is analogous to macroprolactin, where a large, largely inert complex inflates a routine result
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