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It regulates neuronal growth (CREB/BDNF), anti-apoptosis (BAX/Bcl-2), neuronal differentiation (pAkt, MAP2, GAP43, and AGBL4), and neuronal glucose homeostasis (GLUT1, GLUT3, and GLUT4), thereby alleviating neurodegeneration

The intranasal (nose-to-brain) administration method offers a number of advantages, as it avoids first pass effect, is less intrusive, provides a broad surface area for absorption, and reduces nontargeted delivery to minimize systemic exposure [7, 25]

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