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While evidence suggests that some may be using them as quitting aids, more than half of adult e-cigarette users in 2015 (59%) were simultaneous current cigarette users and another 11% had never been regular smokers

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ACKNOWLEDGMENT This work was supported by Grants-in-aid for Comprehensive Research on Cardiovascular Diseases, for Cancer Research, and for the Third-Term Comprehensive Ten-Year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare, Japan, and also by Grants-in-aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan