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Ethics Statement All animal experiments were performed at Lawrence Berkeley National Laboratory and the study was carried out in strict accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health

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When the mean of the HbA1c % levels at the diagnosis according to the smoking status of the parents of the children with Type 1 DM was examined, the mean HbA1c levels of the children whose parents were smokers at diagnosis was 10.94 2.49, while the average of the non-smokers was 10.38 2.77

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