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A clear demonstration was obtained that BPC 157 stimulated both the egr-1 gene (critical in proliferation, differentiation, and inflammation during cholestatic liver injury, cytokine and growth factor generation, and early extracellular matrix (collagen) formation) (Kim et al., 2006

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This pattern suggests continuous daily Dihexa administration beyond 4-6 weeks without rest periods would likely trigger protective receptor downregulation, reducing compound effectiveness over time

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