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If e-cigarettes are used as a means to quit smoking, cigarette smoking should be completely replaced and a plan to ultimately attain freedom from all tobacco products should be advised. Reference: Association of Cigarette and Electronic Cigarette Use Patterns With Levels of Inflammatory and Oxidative Stress Biomarkers Among US Adults: Population Assessment of Tobacco and Health Study by Andrew C

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Choose based on the FDA-recommendation: If your goal is to step down and eventually quit nicotine: Do not exceed 20 mints per day