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Cigarette smokers who are also hypertensive have a 20-fold increased risk of stroke (US Surgeon General, 2004)

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Vulval lichen sclerosus and associated malignancy Before it was realised that VLS could be effectively treated, about 60% of all vulval keratinocyte carcinomas showed histological evidence of adjacent VLS, and it was well established that affected women had a 2 to 6% lifetime risk of developing vulval cancer