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SPMs can decrease levels of pro-inflammatory cytokines, such as IL-1, IL-6, and tumor necrosis factor (TNF)-, through activating their G protein-coupled receptors, thus causing activation of anti-inflammatory transcription factors, such as peroxisome proliferator-activated receptor gamma, and down-regulating intracellular NF-kB signaling pathway (14, 63)

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the average time for its development is three to five months [5]

For patients dealing with gastrointestinal conditions, malabsorption syndromes, or high physiological demand states, the limitation is even more pronounced

The combined calcium elevation from both sources produces a synergistic secretory response

doi: 10.1038/onc.2012.179 294 GreenhalfWGhanehPNeoptolemosJPPalmerDHCoxTFLambRFet al