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[22] GSH is a highly important indirect antioxidant by acting as a coenzyme for various enzymes that couple GSH-to-GSSG oxidation to the reduction of harmful oxidizing species
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However, due to the heterogeneity of the study design (clinimetric parameters used as outcomes, the number of sessions, treatment intervals, and duration of follow-up), the diversity of device settings, and melasma characteristics, comparing these results is complicated [120]
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