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These iron imbalances were associated with behavioral changes characteristic of schizophrenia, including increased anxiety, altered locomotor activity and impaired cognitive functions, suggesting that the altered distribution of iron in these brain regions may contribute to the development of schizophrenia-associated symptoms (192)

Non-Syndromic : Indicating whether the cleft is part of a syndrome (e.g., Van der Woude syndrome) or isolated

This includes elucidating their absorption, distribution, metabolism, and excretion pathways, and verifying that they do not induce toxicity at intended doses

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Together, these studies argue that FSP1 can represent (1) a context-dependent essentiality (for example, metastatic niches) and/or (2) a stand-alone oxidative defense node that becomes rate limiting for tumor survival under physiological stressors encountered in vivo

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