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In addition, mild to moderate gastrointestinal side effects were more frequent in the semaglutide-treated group compared to the placebo-treated group

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If tirzepatide becomes hard to source consistently, your provider may transition you to semaglutide to maintain treatment continuity

In a recent study published in the International Journal of Obesity , researchers investigated the effects of combined glucagon-like peptide 1 (GLP-1) analog and bupropion/naltrexone treatment on weight loss

These drugs are meant to be taken long-term

However, these studies excluded individuals with a history of major depression or psychiatric diseases and reported no significant differences in psychiatric outcomes between liraglutide and placebo groups