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Tobacco product use remains the leading cause of preventable disease and death in the U.S., accounting for more than 480,000 deaths annually, according to the Centers for Disease Control and Prevention

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V., Mwangi, J., Pervan, B., Narula, J., Pineiro, D., & Pinto, F

17 Furthermore, in a model of inhalational tolerance, prolonged cigarette smoke exposure of mice significantly delayed the establishment of tolerance induced by repeated harmless antigen challenges

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Sublingual Sublingual absorption is the typical route of administration of tinctures