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Governments should also continually assess whether existing rulesand the enforcement of those rulesare actually adequate to the task of ensuring respect for human rights, and improve upon them if they are not.[239] IV

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Atherosclerosis predisposes individuals to small-vessel disease, mainly caused by endothelial dysfunction, inflammation, impaired endogenous fibrinolysis and reduced blood flow caused by secondary vasoconstriction, all this contributing to lacunar strokes and white matter lesions