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Importantly, NSCLC patients expressing activating EGFR mutation who were treated with both EGFR TKI and metformin had acquired good quality of life and experienced less side effects [46]

Western blotting analysis showed that PINK1 and Parkin, two classical molecules of the mitophagy pathway, accumulated in mitochondria but decreased in the cytoplasm after nicotine treatment, indicating that PINK1 and Parkin translocated from the cytoplasm to mitochondria and accumulated in mitochondria (Figures 1AF)

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