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Rather than functioning as independent mechanisms, HSPs, autophagy, mitophagy, the UPS, ERAD, and UPR collectively form a multilayered, compensatory system that preserves protein quality and cellular viability

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Lithium modulates autophagy in esophageal and colorectal cancer cells and enhances the efficacy of therapeutic agents in vitro and in vivo

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PMID 23001126

(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear