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1990 Edinburgh University Press paperback edition

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1 Introduction Smoking is a leading behavioral risk factor for various health issues, causing over 175 million deaths and 430 billion years of life lost globally from 1990 to 2021 (1)

A significant improvement of the fit was obtained with a quadratic model, in which the number of cigarettes smoked accounted for almost 39% (adjusted R 2 ) of the variance, and the exposure-response relationship leveled-off near 20 cigarettes (Fig