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People have been smoking herbs for thousands of years across nearly every culture for a wide variety of purposes, from ceremonial to quitting smoking

The data presented in Fig 1D and 1E are key to the authors main conclusions regarding nicotine changes in KCC2, but they are using whole cell recording, which should clamp the Cl concentration gradient

The family history provided by the mother included joint hyperlaxity, abnormal scarring, and early osteoarthritis