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For GLP-1R and GIPR, both tirzepatide and MAR709 showed strikingly decreased receptor internalization compared to mono agonist

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Farkas GJ, Solinsky R, Park AJ

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But it is clearly a benefit

To evaluate aging, the researchers relied on several "epigenetic clocks." These tools estimate biological age by measuring DNA methylation, a pattern of chemical tags that influences how genes are switched on or off without changing the DNA sequence itself