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SIRT1/2 inhibitor, salermide, can increase death receptor 5 expression via the ATF4-ATF3-CHOP axis and contribute to NSCLC cell apoptosis [105]

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Finally, as p23 is also involved in synthesis of prostaglandin E2 (PGE 2 ), the authors evaluated the effects of p23 downregulation on PGE 2 expression, finding that modulation of p23 levels did not affect PGE 2 expression