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These requirements are supplemented by the FD&C Act's misbranding provisions, which require that product labeling and advertising include required warnings

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low certainty27 , 28), and magnitudes of weight gain for both nicotine and non-nicotine e-cigarettes.28 One RCT provided data on adverse events at 12 months that was of very low certainty,39 and a cohort study reported no serious adverse events or differences in smoking-related diseases at 4 years with nicotine e-cigarettes compared with traditional tobacco smoking (certainty could not be evaluated).49 Conclusions from the Cochrane living systematic review on potential harms were similar.24 Resource use Many behavioural interventions are covered by provincial and territorial health care systems or otherwise provided at no charge (e.g., quit lines), and every province and territory has at least limited coverage or rebate programs for pharmacotherapy, including NRT, which is considered a natural health product.50 53 However, people may have to pay out of pocket for some behavioural services or pharmacotherapy