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Due to the global human health threat represented by the ESKAPE pathogens, the WHO included them in the critical priority group for antibiotic research and development 14

Absence of lot analytical characterisation : a contaminated or mis-dosed lot can invalidate an entire experimental series Preregistration and ARRIVE 2.0 Modern animal research standards require protocol preregistration (OSF, PreclinicalTrials.eu) with ex ante definition of primary, secondary criteria and exclusion rules

A common protocol for this stack involves daily injections for up to 30 days

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Lowered inhibitions Slurred speech Poor coordination Confusion Memory loss Difficulty concentrating Difficulty breathing

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