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According to the NCI, the worst period is the first week after ceasing nicotine, with symptoms peaking at Is it better to wean off nicotine or quit cold turkey

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While differences between the studies restricted the ability to make conclusive recommendations regarding the interventions that should be included in practice or community settings, behavioral counselling and an oral examination was a consistent intervention among the studies

Chapter 3

When the heterogeneity between studies is not considered (reflecting a traditional meta-analytic approach), chewing tobacco users were found to have a 2.14 (1.772.57)-fold increased risk of esophageal cancer (Table 2