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Trends Pharmacol Sci 32:700707 Yadav R, France M, Younis N, Hama S, Ammori BJ, Kwok S et al (2012) Extended-release niacin with laropiprant: a review on efficacy, clinical effectiveness and safety

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Owing to concerns about variability in U-Cr values as a function of age, sex, race/ethnicity, and body size, it is recommended that the creatinine-adjusted concentration of an analyte for an individual be compared with a reference value obtained on a similar demographic group (e.g., adults with adults, children with children) [16]