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For instance, PMI conducted a crowd-sourcing validation of their systems toxicology approach to assess IQOS toxicity, in which experts recruited through a third party performed modeling on data collected from mice and humans, concluding nearly no harmful effect of IQOS 115

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So even though cigarettes are neither necessary for lung cancer to develop (non smokers get it too), nor sufficient on their own to cause it in all people all the time (many smokers are cancer free), it is rational to infer a causal relationship