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Interesting question

The most commonly used, Nicotiana tabacum- the Virginia tobacco made into a cash crop by John Smith (likely taught by Pocahontas - whose real name was Matoaka) has no more than 3% of nicotine in it

We can print on magnets, key chains, and more

Crush a fresh leaf and apply it directly to the bee sting for relief

Research shows that nicotine in e-cigarettes increases the infiltration of inflammatory cells, including eosinophils, from the blood into the airways, stimulates the production of type 2 inflammatory cytokines such as IL-4, IL-5, and IL-13, and promotes mucin secretion, exacerbating airway inflammation and hyperresponsiveness, ultimately worsening asthma [66, 67]

Probably everyone these days