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In individuals with type 2 diabetes, we observed that metformin (850 mg) ingested 30 min before an intraduodenal glucose infusion of 8.37 kJ/min (2 kcal/min) reduced the rate of glucose absorption by approximately 10%, and that the augmentation of GLP-1 secretion by metformin was related directly to the magnitude of inhibition of glucose absorption [9]

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