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Bedrosian notes that while bariatric surgery remains the gold standard for weight loss, medications like Ozempic and Wegovy, as well as Mounjaro (FDA-approved to treat type 2 diabetes) and Zepbound (FDA-approved for weight loss) offer a valuable option for individuals who don't qualify for or aren't interested in surgery
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(25), although GLP-1 and GLP-2 are primarily secreted from L cells in the ileum, the secretion of endogenous GLP-1 resulting from fat load occurs within 30 min of lipid ingestion and reaches its peak by 1 h (with the exception of very high doses of around 34 kcal, which peak at 2 h postlipid load)
Mean FibroScan CAP was 286 (SD = 77) dB/m, and the mean elastic modulus was 9.7 (SD = 8.4) kPa
This example draws an important distinction between early and late stage leptin resistance, which may turn out to be conceptually similar to the progression seen in insulin resistance towards type II diabetes
