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Risk differences were higher in men, patients aged 50 years or older, and those with cardiovascular disease or ophthalmic conditions, with minimal differences in women and those younger than 50 years

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The hypoglycaemia risk is primarily with insulin or sulphonylureas, as GLP-1 receptor agonists alone rarely cause hypoglycaemia

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This built-in safety mechanism reduces the risk of GH excess

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Its long-term effects on thyroid function, pancreatic health, cardiovascular outcomes, and bone density remain unknown

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Lancet 395 , 10541062 (2020)

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