Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 19902015: a systematic analysis for the Global Burden of Disease Study 2015
Some studies have shown a link between an increased risk of cardiovascular disease (including heart attacks and stroke) in users of snuff and chewing tobacco, although these risks are not as great as those observed in smokers
The Global Burden of Disease : 2004 Update (PDF)
Similarly, one should be cautious of a type of third-hand exposure to the chemicals in cigarette smoke
Outlook / Prognosis What can I expect if I have oral cancer
In its natural state, nicotine is a weak base