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The truth is much simpler

Selective activation of cannabinoid receptor-2 reduces neuroinflammation after traumatic brain injury via alternative macrophage polarization

[117] Art The earliest depictions of smoking can be found on Classical Mayan pottery from around the 9th century

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The pooled relative risks for the other nine studies that did not allow for multiple confounders were 1.26 and 2.11 for one and 20 cigarettes per day, and the excess relative risk for one cigarette per day was 25% (again, lower than the estimate when we used adjusted relative risks)

[15] Kim Jong Il has called smokers one of the "three main fools of the 21st century", along with people who do not understand music or computers