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CSE exposure increased MKK3 expression and was accompanied by enhanced p38 MAPK phosphorylation and PRKN Ser131 phosphorylation, together with reduced PRKN/PINK1-related mitophagy readouts and increased senescence markers

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With respect to aerosol generation techniques, current machine-based aerosol generation techniques pose several challenges for assessing different product aerosols because many smoking machines and exposure systems were originally designed for use with combustible tobacco cigarettes and do not easily translate to the standard production of e-cigarette aerosols