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Patients carrying these variants often experience greater mitochondrial stress during rapid fat mobilization on semaglutide, potentially benefiting from higher-dose glutathione supplementation (up to 2,000 mg daily) compared to non-carriers

11, the DFU group (DFU-GP) exhibited significantly elevated levels of matrix remodeling enzymes (MMP-13 and ADAMTS-5) and reduced levels of tissue inhibitor TIMP-3 compared to the normal control (NC-GP)

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MaruyamaATsukamotoSNishikawaKYoshidaAHaradaNMotojimaKet alNrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements