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Acknowledgements Acknowledgements This study was supported by grants from the National Heart, Lung and Blood Institute of the National Institutes of Health (RO1HL142511) to YT and MLG, the US Food and Drug Administration and National Cancer Institute (U54CA238110) to MLG, and the National Cancer Institute Grant P30CA016056 involving the use of Roswell Park Core facilities

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Its funding by the National Cancer Institute sends an unequivocal message that informing smokers about safer smokeless substitutes is ethical, credible and worthy of serious consideration

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