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In clinical trials, dose escalation protocols were used to minimize gastrointestinal side effects, starting from lower doses and titrating up to the 10mg maintenance dose over several weeks

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A compromised gut barrier is both a cause and a consequence of dysbiosis, and intervening at the level of mucosal integrity, which is precisely what BPC-157 does in animal models, represents a mechanistically coherent approach to gut-mediated systemic aging