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McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, et al

There are potential solutions to address these changes and to enhance the overall aesthetic outcome

J Pediatr Endocrinol Metab

It is a structured clinical sequence built on published evidence, adapted to the specific skin biology of our patient population, and refined through practice

The trade-off is that youre holding the GH signal on continuously rather than pulsing it, which moves further away from natural physiology and partially overrides the negative feedback loop that protects against over-stimulation