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In a complaint filed late last week, plaintiffs including tobacco giants R.J

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Look at Gracie Abrams, photographed with boyfriend Paul Mescal's arm around her shoulder and a cigarette in her mouth, or to the woman exuding the most enviable aura around: Dua Lipa, whose pre-wedding Instagram photo dump captioned "anyone got a light?" featured a shot of a cigarette dangling from the pop star's pursed lips

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These previous studies [12,13,14,15,16,17] had several limitations such as the inclusion of relatively small number of cases, especially for rare type of congenital anomalies (i.e., being underpowered to detect small or moderate risk effect), the use of case-control design (i.e., being more prone to selection bias), or insufficient adjustment for potential confounders (i.e., being more prone to confounding bias)

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