The erlotinib and metformin combination also enhanced AMPK-dependent phosphorylation of acetyl-coA carboxylase (ACC), a major downstream effector of AMPK in lipid metabolism, and attenuated mTOR-mediated 4EBP1 phosphorylation and Ki67 cell proliferation marker in the tumor tissues (Fig
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[DOI] [PubMed] [Google Scholar] 20.Oral mucosal lesions in children from 0 to 12 years old: ten years' experience
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