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Cardiovascular strain and common side effects MedlinePlus notes that nicotine replacement therapy can raise heart rate and blood pressure, and that side effects are more likely with higher doses (including headaches, nausea, digestive issues, and sleep disturbances)

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adults, 20102011

Not included in this map but important to remember is that local cigarette taxes also apply in some states

State in Cents per Pack Source: Campaign for Tobacco Free Kids