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97 The effect of smoking on the levels of salivary immunoglobulins has been widely documented, 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 with most studies reporting a significant reduction in the SIgA content under the influence of smoking

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Therefore, it is added to strong, full tobacco blends and sometimes replaces Latakia in English-style tobaccos