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In 2021, the global number of deaths from smoking-related bladder cancer was 58766.87 (95% UI: 49381.3470891.72), and the number of disability-adjusted life years (DALYs) attributable to smoking-related bladder cancer was 107082.78 (95% UI: 87698.70129617.13)

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The core laryngeal microbiota was dominated by Comamonadaceae , and increased Streptococcus abundance in benign vocal fold disease suggested its potential role in disease development