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Based on these results, the melatonin-inducible system using MTNR1A was identified as the most promising approach for circadian rhythm-driven transgene expression and was selected for further optimization and characterization

A current drawback of intracellular roGFP2-based mechanistic studies is, however, that the mechanisms and structure-function relationships still have to be validated in vitro

Through its interaction with CAan enzyme essential for maintaining the carbon dioxidebicarbonate balance and physiological pHPolmacoxib may modulate COX-2 inhibition in cardiovascular tissues where both pathways coexist