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Sung BH et al

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Common side effects: Nausea, constipation, diarrhea, or mild stomach upsetusually temporary and manageable

This interval allows: GI side effects (nausea, vomiting, diarrhea) from the current dose level to subside The body to adapt to the rate of gastric emptying at that dose Clinicians to assess tolerability before increasing further Time to reach maximum dose week 20 (after five four-week steps: 1mg, 2mg, 4mg, 8mg, 12mg)

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Cysteinyl-leukotriene1 receptor is a potent target for the prevention and treatment of human urological cancer