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In some embodiments, the otic composition or formulation comprises less than 9% by weight of C1-C4 alcohols or C1-C4 glycols

For instance, at physiologic relative low concentrations, secondary BAs exert anti-inflammatory properties, inducing a partial transformation from M1 to M2 phenotype of macrophages and inhibiting the release of pro-inflammatory cytokines, such as TNF- and IL-6 [25]