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extract significantly increased SOD, GSH-Px, T-AO, and Na + -K + -ATPcase levels, decreased NF-, IL-1, IL-6, MDA, and LDH levels, and inhibited the NF-B/NLRP3 signaling pathway, which further corrected the imbalance in energy metabolism and maintained the integrity of the BBB, thereby alleviates hypobaric hypoxia-induced brain injury (8000 m, exposed to a FLYDWC50-II C Fenglei hypobaric hypoxic chamber for 48 h) (Xie et al., 2022)

Whether declining MOTS-c is a cause or consequence of this deterioration is still being resolved, but the correlation is striking enough that some researchers have proposed plasma MOTS-c as a biomarker of mitochondrial vitality and metabolic age

Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells

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114 SgarbantiR.NencioniL.AmatoreD.ColuccioP.FraternaleA.SaleP.et al (2011)