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Why peptides are particularly challenging for sublingual delivery Peptides like semaglutide and tirzepatide are large molecules compared to many sublingual drugs

The incretin of key relevance with semaglutide is GLP-1 (Glucagon-Like-Peptide-1)

The result is a clear tradeoff

The injection technique guide covers proper administration for all GLP-1 formulations including liraglutide

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None of that says what would happen if some smaller dose had been used in a clinical trial, such as 1mg of tirzepatide (40% of its standard starting dose and 6.7% of the full dose) or 0.1mg of semaglutide (40% of its standard starting dose and 4.2% of the full dose)