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In 2022, tirzepatide was launched, becoming the worlds first new-generation drug that acts on both GLP-1R/GIPR targets

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Role 1: Mechanical bulk and motility

This list is often tiered, with drugs in lower tiers (like Tier 1) having lower co-pays and drugs in higher, more expensive tiers (like Tier 3 or 4) costing you significantly more out-of-pocket

At week 26, the primary HbA1c endpoint was missing for 3.7% and 5.5% of patients randomized to placebo and RYBELSUS 14 mg, respectively

While there are no major, direct drug-to-drug contraindications between these two, the way they affect your digestive system matters