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If the volume is so small that the peptide doesn't fully dissolve, additional bacteriostatic water can be added

10.1111/all.12351 191 SinghP.SharmaS.RathS

The use of anti-infective agents or pyrimethamine may invalidate diagnostic assays for folic acid and vitamin B12

Other tests could include: Upper endoscopy

FDA CDER 2003 Bioavailability and Bioequivalence Studies for Nasal Aerosols and Nasal Sprays for Local Action (BA/BE Guidance): The definitive guidance for in vitro and in vivo studies required to demonstrate bioequivalence between a generic nasal spray and its Reference Listed Drug (RLD)