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For diabetes management, measurable reductions in hemoglobin A1c typically appear within 4-8 weeks, with maximum effects at 12-16 weeks

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The columns (DAY 1, DAY 2, DAY 3, and DAY 4) represent the average values with the standard deviations

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Metformin increased postprandial GLP-1 secretion compared with placebo ( P = 0.014), and the postprandial glucose excursions were significantly smaller after metformin + saline compared with metformin + Ex9-39 ( P = 0.004)